CALL FOR PAPERS Chronic Kidney Disease and Fibrosis Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease
نویسندگان
چکیده
Eun-Sun Ryu, Mi Jin Kim, Hyun-Soo Shin, Yang-Hee Jang, Hack Sun Choi, Inho Jo, Richard J. Johnson, and Duk-Hee Kang Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Center, Seoul, Korea; Department of Molecular Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Center, Seoul, Korea; and Division of Renal Diseases and Hypertension, University of Colorado-Denver, Aurora, Colorado
منابع مشابه
Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice
Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...
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